NMR Unit

IRBM is a scientific contract research organization (CRO) that stands at the forefront of drug discovery, leveraging a single, unified research facility, located in Pomezia (Rome), Italy, to accelerate team-based breakthroughs and improve efficiencies from initial concept to pre-clinical candidate.

With a history of contributing to several approved drugs, and its own internal pipeline of oncology and other therapeutic assets, IRBM is powered by deep collaborations and decades of expertise from leading global institutions. Our comprehensive in-house capabilities assist partners in achieving key milestones and progressing towards clinical readiness, positioning IRBM as a major player in driving innovation in the pharmaceutical and biotech fields.

Job Description

We are looking for a passionate and talented NMR spectroscopist with proven experience in structural biology and structure-based drug discovery. The successful candidate will join a fast-paced NMR team and will work in a highly collaborative research environment to advance scientific projects involving the study of small molecules, peptides and biomolecules (proteins and nucleic acids). The applicant must have solid training in bio-NMR spectroscopy and a passion for innovative and analytical thinking, a strong drive to acquire new skills, answer complex questions, and tackle technical difficulties. Although not absolutely required for the position, experience with i) NMR characterization of DNA/RNA and/or ii) expression and purification of isotope labelled proteins will be considered a plus.

Key responsibilities

  • Prepare Bio-NMR samples and acquire/analyze spectra of proteins, peptides, nucleic acids and small molecules
  • Interpret independently experimental data and present results to internal project teams and external clients/collaborators
  • Develop and/or implement new NMR assays to probe the structure, dynamics and interactions of biomolecules and ligands
  • Help maintaining an in-house Bio-NMR facility consisting of four NMR spectrometers
  • Perform lab and office duties, such as ordering reagents, organizing inventories and keeping experimental records
  • Contribute intellectually to structure-based drug discovery projects and collaborate with members from other disciplines like medicinal chemistry, biology, etc.

Competencies/skills

  • Strong theoretical knowledge of NMR and hand-on experience in Bruker spectrometer setup
  • Knowledge of multinuclear and multidimensional NMR spectroscopy; experience with NMR-related software for spectra/data analysis
  • Familiarity with the use of biomolecular NMR spectroscopy for studying proteins/nucleic acids/small molecules (necessary additional training will be provided)
  • Outstanding organizational skills, critical thinking and problem-solving abilities
  • Highly collaborative and team-oriented attitude; outstanding oral and written communication skills
  • Excellent knowledge of spoken and written English is mandatory

Qualifications

The applicant must hold a Ph.D. in Structural Biology, Chemical Biology (or related fields) and have at least 2 years of work experience as a postdoc or in an industrial setting with focus on NMR.

During the job interview we will evaluate candidates’ experience and the job offer will be commensurate.

We thank all applicants for their interest, candidates selected for interviews will be contacted.

If you require accommodation to complete a job application, a job interview, or to otherwise participate in the hiring process, please contact careers@irbm.com and mention which vacancy you would like to apply for.

IRBM considers all qualified applicants without discrimination, including on the basis of race, gender, age, disability, gender identity or expression, national origin, religion, sexual orientation, or other protected classes. We nurture an inclusive culture where everyone can show their full potential and enjoy a fulfilling career.